FLUORO-DOPA PET BRAIN STUDY

DATE: 10/2/2005

PROCEDURE:  One hour before fluorine-18 L-DOPA IV injection, the patient took 200 mg of carbidopa orally.  Tomographic images were dynamically acquired on a Siemens/CTI PET scanner and were reconstructed with attenuation correction.  Patlak parametric images were generated for regional analysis of the caudates and putamen using a cerebellar region as the free unbound F-DOPA activity in plasma.

F-18 L-DOPA DOSE: [10]  mCi F-DOPA

SESSION NUMBER: P60000

COMPARISON: None

CLINICAL HISTORY: The patient is a [...]-year-old [fe]male with tremor and mild bradykinesia and rigidity referred to Nuclear Medicine for evaluation of Parkinson's Disease.

FINDINGS: 

SEMIQUANTATIVE UPTAKE INDICES:  

Patlak graphic analysis (Kpat)			

Structure	
(ml / min / mg)	
Right Caudate	
Right Putamen	
Left Caudate	
Left Putamen		
		
Standard Deviation	
Right Caudate SD	
Right Putamen SD	
Left Caudate SD	
Left Putamen SD

CONCLUSIONS:

Decreased activity within both caudate and putamen nuclei bilaterally, with relatively greater activity seen within the caudate nuclei as compared with the putamen nuclei. These findings are compatible with idiopathic Parkinson's disease. 

Normal activity within caudate and putamen nuclei is noted. There is no evidence for Parkinson's disease.

Thank you for referring this patient to the UCLA Nuclear Medicine Clinic.

I, [...], M.D., Ph.D., have reviewed this Nuclear Medicine study personally, and am in full agreement with the findings of the report presented here.